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Supplement

Niacinamide

Vitamin B3: the cheap NAD+ precursor.

Niacinamide (vitamin B3, nicotinamide) is an NAD+ precursor and a well-studied topical for skin. We grade Niacinamide C+ on evidence and B- for worth-it at about $6-10 per month.

C+

Evidence

B-

Worth it

Typical cost: $6-10/month

What it does

Niacinamide (vitamin B3, nicotinamide) is an NAD+ precursor and a well-studied topical for skin. As an oral supplement it is cheap and safe at normal doses, with a modest metabolic rationale.

What the research says

  • Supports NAD+ metabolism

    Evidence: emerging. Raises NAD+ metabolites; functional outcomes less studied than NMN/NR.

  • Skin health (topical use)

    Evidence: moderate. Topical evidence is solid; oral evidence for skin is weaker.

DRAFT: essential nutrient with a real NAD+ rationale, but oral longevity outcomes are unstudied.

Is it worth it?

B-

DRAFT: one of the cheapest NAD+ related options available.

Typical cost

$6-10/month

Common form, not a brand recommendation

Dosage contextestablished

RDA-level doses are established; higher 'longevity' dosing has no consensus.

Safety notes

Well tolerated at normal doses; very high chronic doses can stress the liver. Less flushing than niacin. Talk to your doctor. This page is information, not medical advice.

Longevity Lab Report

Niacinamide news, graded when it happens.

New studies, dose debates, and expert shifts on niacinamide, in one email a week. Free.

Changelog

Last updated 2026-10-15

  • 2026-10-15|Batch 3 entry, DRAFT. Grades provisional; expert positions unsourced unless noted.