Supplement
Apigenin
The chamomile compound in Huberman's sleep stack.
Apigenin is a flavonoid found in chamomile, parsley, and celery. We grade Apigenin C+ on evidence and C+ for worth-it at about $12-18 per month.
Evidence
Worth it
Typical cost: $12-18/month
What it does
Apigenin is a flavonoid found in chamomile, parsley, and celery. It binds weakly to benzodiazepine receptors, which is the proposed mechanism for its mild sedative reputation.
What the research says
May support sleep onset
Evidence: emerging. Human data is mostly from chamomile extracts, not isolated apigenin; direct trials are few.
DRAFT: plausible mechanism and traditional use, but isolated-apigenin human trials are scarce.
What the experts say
Every position links to its source. We include skeptics alongside supporters.
Andrew Huberman
“50mg Apigenin”
Source, 2021 Includes 50mg apigenin in his nightly sleep stack, taken 30-60 minutes before bed.
Is it worth it?
DRAFT: inexpensive, but you are paying mostly for association with the stack.
Typical cost
$12-18/month
Common form, not a brand recommendation
Dosage contextemerging
50 mg in the small sleep trials cited; limited data overall.
Safety notes
Limited human safety data as an isolated supplement. People with ragweed or chamomile allergies should be cautious. Talk to your doctor. This page is information, not medical advice.
Longevity Lab Report
Apigenin news, graded when it happens.
New studies, dose debates, and expert shifts on apigenin, in one email a week. Free.
Changelog
Last updated 2026-10-15
- 2026-10-15|Batch 1 expansion entry, DRAFT. Grades provisional; expert positions unsourced unless noted.
- 2026-10-15|Goals/dosage added; prescription flag set where applicable.