Supplement
Sulforaphane
Rhonda Patrick's signature molecule, from broccoli sprouts.
Sulforaphane is a compound produced when you chew cruciferous vegetables like broccoli sprouts. We grade Sulforaphane C+ on evidence and C for worth-it at about $25-35 per month.
Evidence
Worth it
Typical cost: $25-35/month
What it does
Sulforaphane is a compound produced when you chew cruciferous vegetables like broccoli sprouts. It activates the Nrf2 pathway, the body's own antioxidant and detox defense system.
What the research says
Activates Nrf2 antioxidant defenses
Evidence: moderate. Mechanism well demonstrated in humans via broccoli sprout interventions.
May support markers of metabolic health
Evidence: emerging. Small human trials show signals; larger replication needed.
DRAFT: strong mechanistic story with real but small human trials.
What the experts say
Every position links to its source. We include skeptics alongside supporters.
Rhonda Patrick
“I've really gotten back on the sulforaphane train”
Source Long-time advocate; describes herself as back on the sulforaphane train and emphasizes broccoli sprouts and stabilized supplements.
Christine Houghton
Source, 2023-11-17 Phytochemical and nutrigenomics researcher specializing in sulforaphane; advocates a food-first approach and warns most sulforaphane supplements on the market are a waste of money.
Is it worth it?
DRAFT: broccoli sprouts are nearly free; stabilized supplements cost more for convenience.
Typical cost
$25-35/month
Common form, not a brand recommendation
Dosage contextemerging
30 to 60 mg glucoraphanin equivalents in trials; food sources vary widely.
Safety notes
Food-derived and generally safe. Supplement forms can cause digestive upset. Talk to your doctor if you take thyroid medication. This page is information, not medical advice.
Longevity Lab Report
Sulforaphane news, graded when it happens.
New studies, dose debates, and expert shifts on sulforaphane, in one email a week. Free.
Changelog
Last updated 2026-10-15
- 2026-10-15|Batch 1 expansion entry, DRAFT. Grades provisional; expert positions unsourced unless noted.
- 2026-10-15|Goals/dosage added; prescription flag set where applicable.