Supplement
Resveratrol
The red-wine molecule that launched a thousand headlines.
Resveratrol is a polyphenol from grape skins and red wine. We grade Resveratrol C on evidence and C- for worth-it at about $20-35 per month.
Evidence
Worth it
Typical cost: $20-35/month
What it does
Resveratrol is a polyphenol from grape skins and red wine. It activates sirtuins in animal models, which made it the original longevity hype molecule after early mouse studies.
What the research says
Activates sirtuin pathways in animals
Evidence: moderate. Animal mechanism is real; human translation has disappointed.
Extends human healthspan
Evidence: weak. No human trial has shown longevity or hard clinical outcomes.
May support muscle strength when combined with exercise
Evidence: emerging. One study of 30 adults 65-80: resveratrol plus exercise improved muscle strength, power, and fatigue resistance vs exercise alone. Small and unreplicated.
DRAFT: famous mechanism, poor human record; the gap between the two is the story.
What the experts say
Every position links to its source. We include skeptics alongside supporters.
David Sinclair
“1 gram of resveratrol (shaken into my homemade yogurt).”
Source, 2026-08-27 Takes 1 gram of resveratrol every morning, mixed into his yogurt, as stated in Lifespan.
Bryan Johnson
Source, 2026-03-24 Takes resveratrol daily for its potential mitochondrial function and calorie-restriction-mimicking effects; exact dose not specified.
Charles Brenner
Source, 2024-06-25 Skeptical of resveratrol hype; a podcast interview with him includes a segment explicitly devoted to debunking the myths around resveratrol.
Is it worth it?
DRAFT: moderate cost for a human record that never arrived.
Typical cost
$20-35/month
Common form, not a brand recommendation
Dosage contextemerging
150 to 500 mg per day in trials; bioavailability is poor.
Safety notes
Well tolerated at typical doses. May interact with blood thinners and blood pressure drugs. Talk to your doctor. This page is information, not medical advice.
Longevity Lab Report
Resveratrol news, graded when it happens.
New studies, dose debates, and expert shifts on resveratrol, in one email a week. Free.
Changelog
Last updated 2026-10-15
- 2026-10-15|Batch 1 expansion entry, DRAFT. Grades provisional; expert positions unsourced unless noted.
- 2026-10-15|Goals/dosage added; prescription flag set where applicable.
- 2026-10-15|Second pass: added small exercise-combination strength study; grade unchanged (C).