Supplement
Fadogia
Nigerian shrub with animal-only testosterone claims and real toxicity signals
Fadogia agrestis stem extract raised testosterone and sexual-behavior measures in male rats, putatively by stimulating luteinizing hormone. We grade Fadogia D on evidence and D for worth-it at about $15-25 per month.
Evidence
Worth it
Typical cost: $15-25/month
What it does
Fadogia agrestis stem extract raised testosterone and sexual-behavior measures in male rats, putatively by stimulating luteinizing hormone. There are no published human trials for any use.
What the research says
Raised testosterone and improved sexual-behavior parameters in male rats
Evidence: weak. Yakubu et al. (University of Ilorin) found dose-dependent testosterone changes over 5 days of dosing; all human extrapolation is untested
Any libido or testosterone benefit in humans is unproven
Evidence: needs verification. Zero published human clinical trials exist for fadogia agrestis for any use
The entire evidence base is a handful of animal studies from one research group. No human efficacy data and no human safety data; the same group published dose-dependent testicular harm in rodents.
Is it worth it?
Zero human data plus a real animal toxicity signal makes this a poor spend at any price until human safety and efficacy data exist.
Typical cost
$15-25/month
Common form, not a brand recommendation
Dosage contextno established dose
No human-tested dose exists. Do not use the 300-600 mg/day doses marketed by supplement brands; they are guesses, not evidence.
Safety notes
No human safety data exists. Yakubu et al. 2008 (PMID 18023305) found dose-dependent testicular harm and increased oxidative damage markers at 50-100 mg/kg in rats over 28 days, with recovery only at the lower traditional-equivalent dose (18 mg/kg). Examine.com states no dosage can be recommended. Avoid entirely unless human safety data appears.
Longevity Lab Report
Fadogia news, graded when it happens.
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Changelog
Last updated 2026-10-15
- 2026-10-15|Batch 2 DRAFT entry.