Supplement
Vitamin B6
Useful at RDA levels, risky megadosed.
Vitamin B6 (pyridoxine, or P-5-P) is involved in neurotransmitter synthesis. We grade Vitamin B6 B- on evidence and B for worth-it at about $5-8 per month.
Evidence
Worth it
Typical cost: $5-8/month
What it does
Vitamin B6 (pyridoxine, or P-5-P) is involved in neurotransmitter synthesis. There is modest evidence for PMS symptoms and pregnancy nausea; chronic high doses cause peripheral neuropathy.
What the research says
May ease PMS symptoms
Evidence: moderate. Several RCTs support modest benefit.
Corrects deficiency
Evidence: strong. Deficiency is uncommon but real in some diets.
DRAFT: solid for specific uses, but most people need food-level doses only.
Is it worth it?
DRAFT: cheap and effective where indicated.
Typical cost
$5-8/month
Common form, not a brand recommendation
Dosage contextestablished
RDA range; stay well under 100 mg/day chronically.
Safety notes
Chronic doses above ~100 mg/day risk peripheral neuropathy. Prefer low doses or P-5-P form. Talk to your doctor. This page is information, not medical advice.
Longevity Lab Report
Vitamin B6 news, graded when it happens.
New studies, dose debates, and expert shifts on vitamin b6, in one email a week. Free.
Changelog
Last updated 2026-10-15
- 2026-10-15|Batch 3 entry, DRAFT. Grades provisional; expert positions unsourced unless noted.