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Lipoprotein(a)

A genetically determined, sticky variant of LDL reported in nmol/L or mg/dL. Optimal range: Below 75 nmol/L (below 30 mg/dL) is low risk; 75-125 intermediate; 125 and above (50 mg/dL and above) is high risk.

What it measures

A genetically determined, sticky variant of LDL reported in nmol/L or mg/dL. Levels are set at birth and barely move with lifestyle.

Why it matters

High Lp(a) roughly doubles cardiovascular risk independently of other lipids, and it is estimated that 1 in 5 people have elevated levels. Because it is genetic, testing once is enough.

Optimal ranges

Sourced targets, not just lab reference ranges. Lab ranges describe the population; these describe where the evidence says you want to be.

RangeContext
Below 75 nmol/L (below 30 mg/dL) is low risk; 75-125 intermediate; 125 and above (50 mg/dL and above) is high riskNational Lipid Association 2024 scientific statement categories.

How to improve it

  1. 1

    Test once; levels are genetic and do not respond to diet or exercise

  2. 2

    If high, aggressively control all other risk factors (ApoB, blood pressure)

  3. 3

    Discuss with your doctor: targeted Lp(a)-lowering drugs are in late-stage trials

Connected to

Goals

Longevity

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Educational information, not medical advice. Talk to your doctor before acting on any biomarker result.