Estradiol (Women)
The most potent estrogen, in pg/mL. Optimal range: Premenopausal: roughly 30-400 pg/mL, varying across the cycle. Postmenopausal: below 30 pg/mL without therapy.
What it measures
The most potent estrogen, in pg/mL. In premenopausal women it cycles dramatically across the menstrual cycle; after menopause it falls to very low levels.
Why it matters
Estradiol protects bone, brain, heart, and metabolic health in women. The menopause transition brings rapid decline, with effects on sleep, mood, cognition, and cardiovascular risk. No evidence-based longevity optimum exists.
Optimal ranges
Sourced targets, not just lab reference ranges. Lab ranges describe the population; these describe where the evidence says you want to be.
Sourcing caveat
The range below is a widely cited clinical heuristic. No published guideline target was found, and the source is marked for verification. Treat it as a starting point for a conversation with your doctor, not a settled target.
| Range | Context |
|---|---|
| Premenopausal: roughly 30-400 pg/mL, varying across the cycle. Postmenopausal: below 30 pg/mL without therapy | Standard laboratory reference ranges (Vanderbilt Health Library). These are population reference ranges, not optimized targets; no published longevity target found. |
How to improve it
- 1
Maintain healthy body fat; very low fat can suppress estrogen
- 2
Resistance training supports bone during perimenopause
- 3
Discuss hormone therapy risks and benefits with your doctor during perimenopause
- 4
Track symptoms alongside levels, since ranges are wide
Connected to
Goals
Longevity Lab Report
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Educational information, not medical advice. Talk to your doctor before acting on any biomarker result.